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SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands
The neurotensin receptor 1 represents an important drug target involved in various diseases of the central nervous system. So far, the full exploitation of potential therapeutic activities has been compromised by the lack of compounds with favorable physicochemical and pharmacokinetic properties whi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433701/ https://www.ncbi.nlm.nih.gov/pubmed/28510609 http://dx.doi.org/10.1371/journal.pone.0175842 |