New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats

Sensitive and specific liquid-chromatography tandem mass spectrometry (UPLC-MS/MS) assay has been developed and validated for simultaneous quantification of risperidone (RIS) and its active metabolite 9-hydroxyrisperidone (9-OH-RIS) in rat plasma using olanzapine (OLA) as internal standard (IS). Pha...

Descripción completa

Detalles Bibliográficos
Autores principales: Ezzeldin, Essam, Tammam, Marwa, Abo Talib, Nisreen F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434277/
https://www.ncbi.nlm.nih.gov/pubmed/28553353
http://dx.doi.org/10.1155/2017/1271383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434277/
https://www.ncbi.nlm.nih.gov/pubmed/28553353
http://dx.doi.org/10.1155/2017/1271383

Ejemplares similares