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Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma

BACKGROUND: The prognosis of synovial sarcoma (SS), an aggressive soft tissue sarcoma, remains poor. We previously reported that c-MET or platelet-derived growth factor receptor α (PDGFRα) signalling pathway is related to SS progression based upon the findings of phospho-receptor tyrosine kinase (RT...

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Detalles Bibliográficos
Autores principales: Yamada, Shutaro, Imura, Yoshinori, Nakai, Takaaki, Nakai, Sho, Yasuda, Naohiro, Kaneko, Keiko, Outani, Hidetatsu, Takenaka, Satoshi, Hamada, Kenichiro, Myoui, Akira, Araki, Nobuhito, Ueda, Takafumi, Itoh, Kazuyuki, Yoshikawa, Hideki, Naka, Norifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434537/
https://www.ncbi.nlm.nih.gov/pubmed/28511645
http://dx.doi.org/10.1186/s12885-017-3324-3