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A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions

BACKGROUND: Mechanical and biophysical properties of the cellular microenvironment regulate cell fate decisions. Mesenchymal stem cell (MSC) fate is influenced by past mechanical dosing (memory), but the mechanisms underlying this process have not yet been well defined. We have yet to understand how...

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Detalles Bibliográficos
Autores principales: Peng, Tao, Liu, Linan, MacLean, Adam L, Wong, Chi Wut, Zhao, Weian, Nie, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434622/
https://www.ncbi.nlm.nih.gov/pubmed/28511648
http://dx.doi.org/10.1186/s12918-017-0429-x

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