Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK

BACKGROUND: Statins are widely used cholesterol-lowering drugs that act by inhibiting HMGCoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Recent evidence suggests that statin use may be associated with a decreased risk for Alzheimer disease, although the mechanisms underlying thi...

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Detalles Bibliográficos
Autores principales: Pedrini, Steve, Carter, Troy L, Prendergast, George, Petanceska, Suzana, Ehrlich, Michelle E, Gandy, Sam
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC543463/
https://www.ncbi.nlm.nih.gov/pubmed/15647781
http://dx.doi.org/10.1371/journal.pmed.0020018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC543463/
https://www.ncbi.nlm.nih.gov/pubmed/15647781
http://dx.doi.org/10.1371/journal.pmed.0020018

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