Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

Adverse reactions or lack of response to medications are important concerns for drug development programs. However, faithful predictions of drug metabolism and toxicity are difficult because animal models show only limited translatability to humans. Furthermore, current in vitro systems, such as hep...

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Detalles Bibliográficos
Autores principales: Vorrink, Sabine U., Ullah, Shahid, Schmidt, Staffan, Nandania, Jatin, Velagapudi, Vidya, Beck, Olof, Ingelman-Sundberg, Magnus, Lauschke, Volker M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434660/
https://www.ncbi.nlm.nih.gov/pubmed/28264975
http://dx.doi.org/10.1096/fj.201601375R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434660/
https://www.ncbi.nlm.nih.gov/pubmed/28264975
http://dx.doi.org/10.1096/fj.201601375R

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