A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization

Mendelian randomization (MR) uses genetic data to probe questions of causality in epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent years, it has become commonplace to attempt MR analyses by synthesising summary data estimates of genetic association gleaned...

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Detalles Bibliográficos
Autores principales: Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Davey Smith, George, Sheehan, Nuala, Thompson, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434863/
https://www.ncbi.nlm.nih.gov/pubmed/28114746
http://dx.doi.org/10.1002/sim.7221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434863/
https://www.ncbi.nlm.nih.gov/pubmed/28114746
http://dx.doi.org/10.1002/sim.7221

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