FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan. However, lowering translational efficiency extends rather...

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Detalles Bibliográficos
Autores principales: Dhondt, Ineke, Petyuk, Vladislav A., Cai, Huaihan, Vandemeulebroucke, Lieselot, Vierstraete, Andy, Smith, Richard D., Depuydt, Geert, Braeckman, Bart P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434875/
https://www.ncbi.nlm.nih.gov/pubmed/27626670
http://dx.doi.org/10.1016/j.celrep.2016.07.088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434875/
https://www.ncbi.nlm.nih.gov/pubmed/27626670
http://dx.doi.org/10.1016/j.celrep.2016.07.088

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