Physiologically based pharmacokinetic model for ethyl tertiary‐butyl ether and tertiary‐butyl alcohol in rats: Contribution of binding to α2u–globulin in male rats and high‐exposure nonlinear kinetics to toxicity and cancer outcomes

In cancer bioassays, inhalation, but not drinking water exposure to ethyl tertiary‐butyl ether (ETBE), caused liver tumors in male rats, while tertiary‐butyl alcohol (TBA), an ETBE metabolite, caused kidney tumors in male rats following exposure via drinking water. To understand the contribution of...

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Detalles Bibliográficos
Autores principales: Borghoff, Susan J., Ring, Caroline, Banton, Marcy I., Leavens, Teresa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434881/
https://www.ncbi.nlm.nih.gov/pubmed/27885692
http://dx.doi.org/10.1002/jat.3412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434881/
https://www.ncbi.nlm.nih.gov/pubmed/27885692
http://dx.doi.org/10.1002/jat.3412

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