Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux

OBJECTIVES: To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (K (i) values) of PDE5A1‐dependent guanosine cyclic monophosphate (cGMP) hydrolysis. METHODS: Sildenafil analogues were...

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Detalles Bibliográficos
Autores principales: Subbotina, Anna, Ravna, Aina W., Lysaa, Roy A., Abagyan, Ruben, Bugno, Ryszard, Sager, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Molecular and Clinical Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434896/
https://www.ncbi.nlm.nih.gov/pubmed/28211580
http://dx.doi.org/10.1111/jphp.12693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434896/
https://www.ncbi.nlm.nih.gov/pubmed/28211580
http://dx.doi.org/10.1111/jphp.12693

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