The free energy of locking a ring: Changing a deoxyribonucleoside to a locked nucleic acid

Locked nucleic acid (LNA), a modified nucleoside which contains a bridging group across the ribose ring, improves the stability of DNA/RNA duplexes significantly, and therefore is of interest in biotechnology and gene therapy applications. In this study, we investigate the free energy change between...

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Detalles Bibliográficos
Autores principales: Xu, You, Villa, Alessandra, Nilsson, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434909/
https://www.ncbi.nlm.nih.gov/pubmed/28101966
http://dx.doi.org/10.1002/jcc.24692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434909/
https://www.ncbi.nlm.nih.gov/pubmed/28101966
http://dx.doi.org/10.1002/jcc.24692

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