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Genetically engineered probiotic for the treatment of phenylketonuria (PKU); assessment of a novel treatment in vitro and in the PAH(enu2) mouse model of PKU

Phenylketonuria (PKU) is a genetic disease characterized by the inability to convert dietary phenylalanine to tyrosine by phenylalanine hydroxylase. Given the importance of gut microbes in digestion, a genetically engineered microbe could potentially degrade some ingested phenylalanine from the diet...

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Detalles Bibliográficos
Autores principales:	Durrer, Katherine E., Allen, Michael S., Hunt von Herbing, Ione
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435137/ https://www.ncbi.nlm.nih.gov/pubmed/28520731 http://dx.doi.org/10.1371/journal.pone.0176286

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