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Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy
The dynamic of cancer is intimately linked to a dysregulation of the cell cycle and signalling pathways. It has been argued that selectivity of treatments could exploit loss of checkpoint function in cancer cells, a concept termed “cyclotherapy”. Quantitative approaches that describe these dysregula...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435348/ https://www.ncbi.nlm.nih.gov/pubmed/28467408 http://dx.doi.org/10.1371/journal.pcbi.1005529 |