A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B

Genome-wide RNA interference (RNAi) with pooled and barcoded short-hairpin RNA (shRNA) libraries provides a powerful tool for identifying cellular components that are relevant to the modes/mechanisms of action (MoA) of bioactive compounds. shRNAs that affect cellular sensitivity to a given compound...

Descripción completa

Detalles Bibliográficos
Autores principales: Takase, Shohei, Kurokawa, Rumi, Arai, Daisuke, Kanemoto Kanto, Kind, Okino, Tatsufumi, Nakao, Yoichi, Kushiro, Tetsuo, Yoshida, Minoru, Matsumoto, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435677/
https://www.ncbi.nlm.nih.gov/pubmed/28515454
http://dx.doi.org/10.1038/s41598-017-02016-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435677/
https://www.ncbi.nlm.nih.gov/pubmed/28515454
http://dx.doi.org/10.1038/s41598-017-02016-4

Ejemplares similares