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A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B
Genome-wide RNA interference (RNAi) with pooled and barcoded short-hairpin RNA (shRNA) libraries provides a powerful tool for identifying cellular components that are relevant to the modes/mechanisms of action (MoA) of bioactive compounds. shRNAs that affect cellular sensitivity to a given compound...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435677/ https://www.ncbi.nlm.nih.gov/pubmed/28515454 http://dx.doi.org/10.1038/s41598-017-02016-4 |