Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex

The Hippo pathway is a tumor suppressor pathway that is implicated in the regulation of organ size. The pathway has three components: the upstream regulatory factors, the kinase core, and the downstream transcriptional machinery, which consists of YAP, TAZ (transcription co-activators) and TEAD (tra...

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Detalles Bibliográficos
Autores principales: Kaan, Hung Yi Kristal, Chan, Siew Wee, Tan, Siew Kim Joyce, Guo, Fusheng, Lim, Chun Jye, Hong, Wanjin, Song, Haiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435683/
https://www.ncbi.nlm.nih.gov/pubmed/28515457
http://dx.doi.org/10.1038/s41598-017-02219-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435683/
https://www.ncbi.nlm.nih.gov/pubmed/28515457
http://dx.doi.org/10.1038/s41598-017-02219-9

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