Ligand chain length drives activation of lipid G protein-coupled receptors

Sphingosine-1-phosphate (S1P) is a lipid mediator that can activate five cell membrane G protein-coupled receptors (GPCRs) which carry a variety of essential functions and are promising drug targets. S1P is composed of a polar zwitterionic head-group and a hydrophobic alkyl chain. This implies an ac...

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Detalles Bibliográficos
Autores principales: Troupiotis-Tsaïlaki, Anastassia, Zachmann, Julian, González-Gil, Inés, Gonzalez, Angel, Ortega-Gutiérrez, Silvia, López-Rodríguez, Maria L., Pardo, Leonardo, Govaerts, Cedric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435731/
https://www.ncbi.nlm.nih.gov/pubmed/28515494
http://dx.doi.org/10.1038/s41598-017-02104-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435731/
https://www.ncbi.nlm.nih.gov/pubmed/28515494
http://dx.doi.org/10.1038/s41598-017-02104-5

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