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Functional dissection of NEAT1 using genome editing reveals substantial localization of the NEAT1_1 isoform outside paraspeckles

Large numbers of long noncoding RNAs have been discovered in recent years, but only a few have been characterized. NEAT1 (nuclear paraspeckle assembly transcript 1) is a mammalian long noncoding RNA that is important for the reproductive physiology of mice, cancer development, and the formation of s...

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Detalles Bibliográficos
Autores principales: Li, Ruohan, Harvey, Alan R., Hodgetts, Stuart I., Fox, Archa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435860/
https://www.ncbi.nlm.nih.gov/pubmed/28325845
http://dx.doi.org/10.1261/rna.059477.116