Acute inactivation of the replicative helicase in human cells triggers MCM8–9-dependent DNA synthesis

DNA replication fork progression can be disrupted at difficult to replicate loci in the human genome, which has the potential to challenge chromosome integrity. This replication fork disruption can lead to the dissociation of the replisome and the formation of DNA damage. To model the events stemmin...

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Detalles Bibliográficos
Autores principales: Natsume, Toyoaki, Nishimura, Kohei, Minocherhomji, Sheroy, Bhowmick, Rahul, Hickson, Ian D., Kanemaki, Masato T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435893/
https://www.ncbi.nlm.nih.gov/pubmed/28487407
http://dx.doi.org/10.1101/gad.297663.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435893/
https://www.ncbi.nlm.nih.gov/pubmed/28487407
http://dx.doi.org/10.1101/gad.297663.117

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