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Regulation of DNA demethylation by the XPC DNA repair complex in somatic and pluripotent stem cells
Faithful resetting of the epigenetic memory of a somatic cell to a pluripotent state during cellular reprogramming requires DNA methylation to silence somatic gene expression and dynamic DNA demethylation to activate pluripotency gene transcription. The removal of methylated cytosines requires the b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435894/ https://www.ncbi.nlm.nih.gov/pubmed/28512237 http://dx.doi.org/10.1101/gad.295741.116 |