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Dissection of ubiquitinated protein degradation by basal autophagy

Basal autophagy plays an essential role as a protein quality control system. Although it has been demonstrated that the loss of autophagy results in the accumulation of ubiquitin‐positive aggregates and the development of neurodegenerative diseases, the precise autophagy substrate(s) remain unclear....

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Detalles Bibliográficos
Autores principales: Takayama, Kaori, Matsuura, Akira, Itakura, Eisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435929/
https://www.ncbi.nlm.nih.gov/pubmed/28369861
http://dx.doi.org/10.1002/1873-3468.12641