Amplification of unscheduled DNA synthesis signal enables fluorescence-based single cell quantification of transcription-coupled nucleotide excision repair

Nucleotide excision repair (NER) comprises two damage recognition pathways: global genome NER (GG-NER) and transcription-coupled NER (TC-NER), which remove a wide variety of helix-distorting lesions including UV-induced damage. During NER, a short stretch of single-stranded DNA containing damage is...

Descripción completa

Detalles Bibliográficos
Autores principales: Wienholz, Franziska, Vermeulen, Wim, Marteijn, Jurgen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436002/
https://www.ncbi.nlm.nih.gov/pubmed/28088761
http://dx.doi.org/10.1093/nar/gkw1360