Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

PHF8 is a histone demethylase with specificity for repressive modifications. While mutations of PHF8 have been associated with cognitive defects and cleft lip/palate, its role in mammalian development and physiology remains unexplored. Here, we have generated a Phf8 knockout allele in mice to examin...

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Detalles Bibliográficos
Autores principales: Walsh, Ryan M., Shen, Erica Y., Bagot, Rosemary C., Anselmo, Anthony, Jiang, Yan, Javidfar, Behnam, Wojtkiewicz, Gregory J., Cloutier, Jennifer, Chen, John W., Sadreyev, Ruslan, Nestler, Eric J., Akbarian, Schahram, Hochedlinger, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436068/
https://www.ncbi.nlm.nih.gov/pubmed/28485378
http://dx.doi.org/10.1038/ncomms15142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436068/
https://www.ncbi.nlm.nih.gov/pubmed/28485378
http://dx.doi.org/10.1038/ncomms15142

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