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EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration

Following gut epithelial damage, epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signalling triggers Drosophila intestinal stem cells to produce enteroblasts (EBs) and enterocytes (ECs) that regenerate the gut. As EBs differentiate into ECs, they become postmitotic, but...

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Detalles Bibliográficos
Autores principales: Xiang, Jinyi, Bandura, Jennifer, Zhang, Peng, Jin, Yinhua, Reuter, Hanna, Edgar, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436070/
https://www.ncbi.nlm.nih.gov/pubmed/28485389
http://dx.doi.org/10.1038/ncomms15125