Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

Oncogenic Ras mutants, frequently detected in human cancers, are high-priority anticancer drug targets. However, direct inhibition of oncogenic Ras mutants with small molecules has been extremely challenging. Here we report the development of a human IgG1 format antibody, RT11, which internalizes in...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, Seung-Min, Choi, Dong-Ki, Jung, Keunok, Bae, Jeomil, Kim, Ji-sun, Park, Seong-wook, Song, Ki-Hoon, Kim, Yong-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436137/
https://www.ncbi.nlm.nih.gov/pubmed/28489072
http://dx.doi.org/10.1038/ncomms15090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436137/
https://www.ncbi.nlm.nih.gov/pubmed/28489072
http://dx.doi.org/10.1038/ncomms15090

Ejemplares similares