Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming

The presynaptic active zone protein Munc13 is essential for neurotransmitter release, playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C(2)A domain of Munc13 inhibits the priming function by homodimerization, and that RIM disrupts the autoinhibitory homodimer...

Descripción completa

Detalles Bibliográficos
Autores principales: Camacho, Marcial, Basu, Jayeeta, Trimbuch, Thorsten, Chang, Shuwen, Pulido-Lozano, Cristina, Chang, Shwu-Shin, Duluvova, Irina, Abo-Rady, Masin, Rizo, Josep, Rosenmund, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436228/
https://www.ncbi.nlm.nih.gov/pubmed/28489077
http://dx.doi.org/10.1038/ncomms15293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436228/
https://www.ncbi.nlm.nih.gov/pubmed/28489077
http://dx.doi.org/10.1038/ncomms15293

Ejemplares similares