Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice

Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles (NFTs); these hormones can regulate Tau phosphorylation and the principal kinase...

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Detalles Bibliográficos
Autores principales: Neri-Gómez, Teresa, Espinosa-Raya, Judith, Díaz-Cintra, Sofía, Segura-Uribe, Julia, Orozco-Suárez, Sandra, Gallardo, Juan Manuel, Guerra-Araiza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436357/
https://www.ncbi.nlm.nih.gov/pubmed/28553339
http://dx.doi.org/10.4103/1673-5374.205098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436357/
https://www.ncbi.nlm.nih.gov/pubmed/28553339
http://dx.doi.org/10.4103/1673-5374.205098

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