Cargando…

[(18)F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease

Microglial activation is a key pathological feature of Alzheimer's disease (AD). PET imaging of translocator protein 18 kDa (TSPO) is a strategy to detect microglial activation in vivo. Here we assessed flutriciclamide ([(18)F]GE-180), a new second-generation TSPO-PET radiotracer, for its abili...

Descripción completa

Detalles Bibliográficos
Autores principales:	James, Michelle L., Belichenko, Nadia P., Shuhendler, Adam J., Hoehne, Aileen, Andrews, Lauren E., Condon, Christina, Nguyen, Thuy-Vi V., Reiser, Vladimer, Jones, Paul, Trigg, William, Rao, Jianghong, Gambhir, Sanjiv S., Longo, Frank M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436503/ https://www.ncbi.nlm.nih.gov/pubmed/28529627 http://dx.doi.org/10.7150/thno.17666

Ejemplares similares

TSPO–PET imaging using [(18)F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75(NTR) ligand LM11A-31
por: Simmons, Danielle A, et al.
Publicado: (2018)

A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
por: Simmons, Danielle A., et al.
Publicado: (2014)

Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice
por: Pu, Kanyi, et al.
Publicado: (2014)

Investigation of 6-[(18)F]-Fluoromaltose as a Novel PET Tracer for Imaging Bacterial Infection
por: Gowrishankar, Gayatri, et al.
Publicado: (2014)

Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with (18)F-GE-180, a Radiotracer for Translocator Protein (TSPO)
por: Hellberg, Sanna, et al.
Publicado: (2018)

Kinetic analysis of the translocator protein positron emission tomography ligand [(18)F]GE-180 in the human brain
por: Feeney, Claire, et al.
Publicado: (2016)

Expression of murine Lm-1 locus. Lm-1 determinants on lymphocytes and macrophages, and effects of Lm-1 incompatibility on bone marrow grafts
Publicado: (1985)

Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington’s Disease: Preclinical Evidence with the p75(NTR) Ligand LM11A-31
por: Simmons, Danielle A., et al.
Publicado: (2021)

Self-luminescing BRET-FRET near infrared dots for in vivo lymph node mapping and tumor imaging
por: Xiong, Liqin, et al.
Publicado: (2012)

Quadrupoles type IX and X: Drawings 202-010 LM 1 and 202-013 LM 1
por: Boltezar, E
Publicado: (1974)

In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid
por: Tremoleda, J. L., et al.
Publicado: (2016)

A measurement of the photonuclear interactions of 180 GeV muons in iron
por: Alexa, C, et al.
Publicado: (2003)

Turbinas de gas LM2500/
por: Aguilar Domínguez, Hugo
Publicado: (2005)

The contribution of LM to the neuroscience of movement vision
por: Zihl, Josef, et al.
Publicado: (2015)

ultraLM and miniLM: Locator tools for smart tracking of fluorescent cells in correlative light and electron microscopy
por: Brama, Elisabeth, et al.
Publicado: (2016)

Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation
por: Ding, Zhaoqing, et al.
Publicado: (2014)

A precise measurement of 180 GeV muon energy losses in iron
por: Amaral, P, et al.
Publicado: (2001)

Enzymatic characterization and structure-function relationship of two chitinases, LmChiA and LmChiB, from Listeria monocytogenes
por: Churklam, Wasinee, et al.
Publicado: (2020)

A measurement of the photonuclear interactions of 180 GeV muons with the TILECAL Module and prototypes
por: Leitner, R
Publicado: (1999)

In response to: Anatomy of (18)F-GE180, a failed radioligand for the TSPO protein
por: Albert, Nathalie L., et al.
Publicado: (2020)

Capots de protection colonne 750 kV: Dessins 105-004LM2 et 105-005LM3
por: Férigoule, C
Publicado: (1975)

Specification of solenoids ø 50/220 and ø 60/240: Drawings 029-005LM3 and 034-002LM2
por: Boltezar, E
Publicado: (1985)

Capots de protection colonne 750 kV: Dessins 105.004LM2 et 105.005LM3
por: Férigoule, C
Publicado: (1975)

The Effect of LM25 and LM50 on Hypoglycemia in Chinese T2DM Patients: Post Hoc Analysis of a Randomized Crossover Trial
por: Li, Wei, et al.
Publicado: (2020)

Lm-LLO-Based Immunotherapies and HPV-Associated Disease
por: Wallecha, Anu, et al.
Publicado: (2012)

Leptons + Jets + Missing Energy Analysis at LM1
por: Chiorboli, Massimiliano, et al.
Publicado: (2006)

Duoplasmatron I: Drawing no 101-009 LM1
por: Boltezar, E
Publicado: (1974)

RFQ vane: Drawing 029-100LM2
por: Boltezar, E
Publicado: (1981)

The LM Posterior Root Stabilizes the ACL Deficient Knee
por: Moatshe, Gilbert, et al.
Publicado: (2017)

Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid).
por: Bibby, M. C., et al.
Publicado: (1987)

LmCht5-1 and LmCht5-2 Promote the Degradation of Serosal and Pro-Nymphal Cuticles during Locust Embryonic Development
por: Zhang, Tingting, et al.
Publicado: (2022)

BAP31 regulates IRAK1-dependent neuroinflammation in microglia
por: Liu, Xia, et al.
Publicado: (2019)

Data on specificity of [(18)F]GE180 uptake for TSPO expression in rodent brain and myocardium
por: Deussing, Maximilian, et al.
Publicado: (2018)

TSPO PET signal using [(18)F]GE180 is associated with survival in recurrent gliomas
por: Quach, Stefanie, et al.
Publicado: (2022)

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing
por: Shuhendler, Adam J., et al.
Publicado: (2014)

[(18)F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis
por: Hoehne, Aileen, et al.
Publicado: (2018)

Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia
por: Nguyen, Thuy-Vi V., et al.
Publicado: (2018)

Quadrupoles for Linac structure: Drawing 301-017LM2
por: Boltezar, E
Publicado: (1974)

Quadrupole type VI: Drawing 202-001 LM 2
por: Boltezar, E
Publicado: (1974)

Variable aperture mechanism: Drawing No 225-001LM1
por: Betty, G
Publicado: (1978)

Cannot write session to /tmp/vufind_sessions/sess_v07mmpqp5e53i9ru00jtacdj91