Splicing factor SF3B1(K700E) mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2. Mutations in SF3B1 are associated with 80% cases of refractory anemia with ring sideroblast (RARS), a subtype of MDS. SF3B1(K700E) is the most frequently...

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Detalles Bibliográficos
Autores principales: Jin, Shuiling, Su, Hairui, Tran, Ngoc-Tung, Song, Jing, Lu, Sydney S., Li, Ying, Huang, Suming, Abdel-Wahab, Omar, Liu, Yanyan, Zhao, Xinyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436638/
https://www.ncbi.nlm.nih.gov/pubmed/28545085
http://dx.doi.org/10.1371/journal.pone.0175523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436638/
https://www.ncbi.nlm.nih.gov/pubmed/28545085
http://dx.doi.org/10.1371/journal.pone.0175523

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