Cargando…

Splicing factor SF3B1(K700E) mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2. Mutations in SF3B1 are associated with 80% cases of refractory anemia with ring sideroblast (RARS), a subtype of MDS. SF3B1(K700E) is the most frequently...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Shuiling, Su, Hairui, Tran, Ngoc-Tung, Song, Jing, Lu, Sydney S., Li, Ying, Huang, Suming, Abdel-Wahab, Omar, Liu, Yanyan, Zhao, Xinyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436638/ https://www.ncbi.nlm.nih.gov/pubmed/28545085 http://dx.doi.org/10.1371/journal.pone.0175523

Ejemplares similares

Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts
por: Conte, Simona, et al.
Publicado: (2015)

Role of Arabidopsis Splicing factor SF1 in Temperature-Responsive Alternative Splicing of FLM pre-mRNA
por: Lee, Keh Chien, et al.
Publicado: (2020)

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug
por: Alors-Perez, Emilia, et al.
Publicado: (2021)

Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing
por: Corioni, Margherita, et al.
Publicado: (2011)

Mechanistic Insights of Aberrant Splicing with Splicing Factor Mutations Found in Myelodysplastic Syndromes
por: Kataoka, Naoyuki, et al.
Publicado: (2021)

Deficiency of Splicing Factor 1 (SF1) Reduces Intestinal Polyp Incidence in Apc(Min/)(+) Mice
por: Godavarthi, Jyotsna D., et al.
Publicado: (2020)

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
por: Harbour, J. William, et al.
Publicado: (2013)

A functional network of gastric-cancer-associated splicing events controlled by dysregulated splicing factors
por: Cheng, Shanshan, et al.
Publicado: (2020)

In-depth analysis of alternative splicing landscape in multiple myeloma and potential role of dysregulated splicing factors
por: Aktas Samur, Anil, et al.
Publicado: (2022)

In Silico Analysis of a Highly Mutated Gene in Cancer Provides Insight into Abnormal mRNA Splicing: Splicing Factor 3B Subunit 1(K700E) Mutant
por: Samy, Asmaa, et al.
Publicado: (2020)

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts
por: Mupo, A, et al.
Publicado: (2017)

The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1
por: Guo, Jing, et al.
Publicado: (2022)

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1
por: Panzeri, Valentina, et al.
Publicado: (2023)

The SF3b complex: splicing and beyond
por: Sun, Chengfu
Publicado: (2020)

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF
por: Chen, Zhiqi, et al.
Publicado: (2010)

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia
por: Tanaka, Atsushi, et al.
Publicado: (2022)

Splicing Dysregulation as Oncogenic Driver and Passenger Factor in Brain Tumors
por: Bielli, Pamela, et al.
Publicado: (2019)

SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity
por: Kim Guisbert, Karen S., et al.
Publicado: (2017)

Understanding the Impact of Aberrant Splicing in Coagulation Factor V Deficiency
por: Paraboschi, Elvezia Maria, et al.
Publicado: (2019)

Background splicing as a predictor of aberrant splicing in genetic disease
por: D, Alexieva, et al.
Publicado: (2022)

Dysregulation of RNA Splicing in Tauopathies
por: Apicco, Daniel J., et al.
Publicado: (2019)

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins
por: Crisci, Angela, et al.
Publicado: (2015)

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain
por: Wang, Guohao, et al.
Publicado: (2015)

The High Level of Aberrant Splicing of ISCU in Slow-Twitch Muscle May Involve the Splicing Factor SRSF3
por: Rawcliffe, Denise F. R., et al.
Publicado: (2016)

Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1
por: Nameki, Nobukazu, et al.
Publicado: (2022)

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
por: Kitamura, Koji, et al.
Publicado: (2021)

New insights into minor splicing—a transcriptomic analysis of cells derived from TALS patients
por: Cologne, Audric, et al.
Publicado: (2019)

Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice
por: Smart, Nicola, et al.
Publicado: (2017)

Aberrant expression and regulatory network of splicing factor-SRSF3 in tumors
por: Che, Yingying, et al.
Publicado: (2020)

The Splicing Factor SF2 Is Critical for Hyperproliferation and Survival in a TORC1-Dependent Model of Early Tumorigenesis in Drosophila
por: Parniewska, Malgorzata Maria, et al.
Publicado: (2020)

XE7: A novel splicing factor that interacts with ASF/SF2 and ZNF265
por: Mangs, A. Helena, et al.
Publicado: (2006)

MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF
por: Miao, Hui, et al.
Publicado: (2022)

Dysregulated minor intron splicing in cancer
por: Nishimura, Koutarou, et al.
Publicado: (2022)

Aberrant splicing and drug resistance in AML
por: de Necochea-Campion, Rosalia, et al.
Publicado: (2016)

Aberrant alternative splicing in breast cancer
por: Yang, Quan, et al.
Publicado: (2019)

Dysregulated Rbfox2 produces aberrant splicing of Ca(V)1.2 calcium channel in diabetes-induced cardiac hypertrophy
por: Li, Pengpeng, et al.
Publicado: (2023)

Splicing factor SF3B1 mutations and ring sideroblasts in myelodysplastic syndromes: a Brazilian cohort screening study
por: Donaires, Flávia Sacilotto, et al.
Publicado: (2016)

Splicing factor SF3B1 promotes endometrial cancer progression via regulating KSR2 RNA maturation
por: Popli, Pooja, et al.
Publicado: (2020)

The RNA Binding Protein RBM38 (RNPC1) Regulates Splicing during Late Erythroid Differentiation
por: Heinicke, Laurie A., et al.
Publicado: (2013)

Aberrant Splicing in GJB1 and the Relevance of 5′ UTR in CMTX1 Pathogenesis
por: Boso, Federica, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o2c5c85tibj7rp2tfkse04bkc3