The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria

Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective Pklr(I90N) genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection with Plasmodium chabaudi AS, suggesting a genetic...

Descripción completa

Detalles Bibliográficos
Autores principales: Laroque, Aurélie, Min-Oo, Gundula, Tam, Mifong, Ponka, Prem, Stevenson, Mary M., Gros, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436716/
https://www.ncbi.nlm.nih.gov/pubmed/28542307
http://dx.doi.org/10.1371/journal.pone.0177818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436716/
https://www.ncbi.nlm.nih.gov/pubmed/28542307
http://dx.doi.org/10.1371/journal.pone.0177818

Ejemplares similares