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The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria

Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective Pklr(I90N) genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection with Plasmodium chabaudi AS, suggesting a genetic...

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Detalles Bibliográficos
Autores principales:	Laroque, Aurélie, Min-Oo, Gundula, Tam, Mifong, Ponka, Prem, Stevenson, Mary M., Gros, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436716/ https://www.ncbi.nlm.nih.gov/pubmed/28542307 http://dx.doi.org/10.1371/journal.pone.0177818

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