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Development of a versatile oncolytic virus platform for local intra-tumoural expression of therapeutic transgenes
Oncolytic viruses which infect and kill tumour cells can also be genetically modified to express therapeutic genes that augment their anti-cancer activities. Modifying oncolytic viruses to produce effective cancer therapies is challenging as encoding transgenes often attenuates virus activity or pre...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436815/ https://www.ncbi.nlm.nih.gov/pubmed/28542292 http://dx.doi.org/10.1371/journal.pone.0177810 |