Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa

Factor XIa (FXIa) is a serine protease that catalyzes the activation of Factor IX (FIX) in the blood coagulation cascade. FXIa and its precursor FXI are emergent therapeutic targets for the development of safer anticoagulant agents. Here, we sought a novel DNA-based agent to inhibit FXIa. Towards th...

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Detalles Bibliográficos
Autores principales: Donkor, David A., Bhakta, Varsha, Eltringham-Smith, Louise J., Stafford, Alan R., Weitz, Jeffrey I., Sheffield, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437010/
https://www.ncbi.nlm.nih.gov/pubmed/28522812
http://dx.doi.org/10.1038/s41598-017-02055-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437010/
https://www.ncbi.nlm.nih.gov/pubmed/28522812
http://dx.doi.org/10.1038/s41598-017-02055-x

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