TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22

The adaptor protein TNF receptor associated factor (TRAF) 3 is required for effective TCR signaling and normal T cell effector functions, and associates with the CD3/CD28 complex upon activation. To determine how TRAF3 promotes proximal TCR signaling, we studied TRAF3-deficient mouse and human T cel...

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Detalles Bibliográficos
Autores principales: Wallis, Alicia M., Wallace, Ellie C., Hostager, Bruce S., Yi, Zuoan, Houtman, Jon C. D., Bishop, Gail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437045/
https://www.ncbi.nlm.nih.gov/pubmed/28522807
http://dx.doi.org/10.1038/s41598-017-02280-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437045/
https://www.ncbi.nlm.nih.gov/pubmed/28522807
http://dx.doi.org/10.1038/s41598-017-02280-4

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