Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis

In order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adjuvant properties of a non-toxic derivative of Escherichia coli heat labile enterotoxin (LT), LTAK63. We have constructed rBCG strains expressing LTAK63 at different expression levels. Mice immunized wi...

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Detalles Bibliográficos
Autores principales: Nascimento, Ivan P., Rodriguez, Dunia, Santos, Carina C., Amaral, Eduardo P., Rofatto, Henrique K., Junqueira-Kipnis, Ana P., Gonçalves, Eduardo D. C., D’Império-Lima, Maria R., Hirata, Mario H., Silva, Celio L., Winter, Nathalie, Gicquel, Brigitte, Mills, Kingston H. G., Pizza, Mariagrazia, Rappuoli, Rino, Leite, Luciana C. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437048/
https://www.ncbi.nlm.nih.gov/pubmed/28522873
http://dx.doi.org/10.1038/s41598-017-02003-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437048/
https://www.ncbi.nlm.nih.gov/pubmed/28522873
http://dx.doi.org/10.1038/s41598-017-02003-9

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