Single-cell, single-mRNA analysis of Ccnb1 promoter regulation

Promoter activation drives gene transcriptional output. Here we report generating site-specifically integrated single-copy promoter transgenes and measuring their expression to indicate promoter activities at single-mRNA level. mRNA counts, Pol II density and Pol II firing rates of the Ccnb1 promote...

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Detalles Bibliográficos
Autores principales: Vishnoi, Nidhi, Yao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437063/
https://www.ncbi.nlm.nih.gov/pubmed/28522800
http://dx.doi.org/10.1038/s41598-017-02240-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437063/
https://www.ncbi.nlm.nih.gov/pubmed/28522800
http://dx.doi.org/10.1038/s41598-017-02240-y

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