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Single-cell, single-mRNA analysis of Ccnb1 promoter regulation
Promoter activation drives gene transcriptional output. Here we report generating site-specifically integrated single-copy promoter transgenes and measuring their expression to indicate promoter activities at single-mRNA level. mRNA counts, Pol II density and Pol II firing rates of the Ccnb1 promote...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437063/ https://www.ncbi.nlm.nih.gov/pubmed/28522800 http://dx.doi.org/10.1038/s41598-017-02240-y |