GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

The accumulation of soluble amyloid-β (Aβ) peptides produces profound neuronal changes in the brain during the pathogenesis of Alzheimer's disease. Excessive levels of Aβ disrupt excitatory synaptic transmission by promoting the removal of synaptic AMPA receptors (AMPARs), dendritic spine loss,...

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Detalles Bibliográficos
Autores principales: Guntupalli, Sumasri, Jang, Se Eun, Zhu, Tianyi, Huganir, Richard L., Widagdo, Jocelyn, Anggono, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437227/
https://www.ncbi.nlm.nih.gov/pubmed/28377502
http://dx.doi.org/10.1074/jbc.M116.774554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437227/
https://www.ncbi.nlm.nih.gov/pubmed/28377502
http://dx.doi.org/10.1074/jbc.M116.774554

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