Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein

Designing an effective HIV-1 envelope glycoprotein (Env) immunogen for elicitation of broadly neutralizing antibodies (bNAbs) is a challenging task because of the high sequence diversity, heavy glycosylation, and inherent meta-stability of Env. Based on the antigenic profile of recently isolated bNA...

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Detalles Bibliográficos
Autores principales: Ahmed, Shubbir, Shrivastava, Tripti, Kumar, Naresh, Ozorowski, Gabriel, Ward, Andrew B., Chakrabarti, Bimal K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437231/
https://www.ncbi.nlm.nih.gov/pubmed/28283570
http://dx.doi.org/10.1074/jbc.M117.776419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437231/
https://www.ncbi.nlm.nih.gov/pubmed/28283570
http://dx.doi.org/10.1074/jbc.M117.776419

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