CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin

Many pathogenic bacteria produce pore-forming toxins to attack and kill human cells. We have determined the 4.5 Å structure of the ~2.2 MDa pore complex of pneumolysin, the main virulence factor of Streptococcus pneumoniae, by cryoEM. The pneumolysin pore is a 400 Å ring of 42 membrane-inserted mono...

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Detalles Bibliográficos
Autores principales: van Pee, Katharina, Neuhaus, Alexander, D'Imprima, Edoardo, Mills, Deryck J, Kühlbrandt, Werner, Yildiz, Özkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437283/
https://www.ncbi.nlm.nih.gov/pubmed/28323617
http://dx.doi.org/10.7554/eLife.23644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437283/
https://www.ncbi.nlm.nih.gov/pubmed/28323617
http://dx.doi.org/10.7554/eLife.23644

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