Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none of them can fully explain its toxicity. Here we use a combination of directed evolution and chemical and...

Descripción completa

Detalles Bibliográficos
Autores principales: Morales, Eduardo H., Pinto, Camilo A., Luraschi, Roberto, Muñoz-Villagrán, Claudia M., Cornejo, Fabián A., Simpkins, Scott W., Nelson, Justin, Arenas, Felipe A., Piotrowski, Jeff S., Myers, Chad L., Mori, Hirotada, Vásquez, Claudio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437285/
https://www.ncbi.nlm.nih.gov/pubmed/28492282
http://dx.doi.org/10.1038/ncomms15320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437285/
https://www.ncbi.nlm.nih.gov/pubmed/28492282
http://dx.doi.org/10.1038/ncomms15320

Ejemplares similares