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Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none of them can fully explain its toxicity. Here we use a combination of directed evolution and chemical and...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437285/ https://www.ncbi.nlm.nih.gov/pubmed/28492282 http://dx.doi.org/10.1038/ncomms15320 |