Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

Metastases are the leading cause of mortality in patients with cancer. Metastasis formation requires cancer cells to adapt their cellular phenotype. However, how metabolism supports this adaptation of cancer cells is poorly defined. We use 2D versus 3D cultivation to induce a shift in the cellular p...

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Detalles Bibliográficos
Autores principales: Elia, Ilaria, Broekaert, Dorien, Christen, Stefan, Boon, Ruben, Radaelli, Enrico, Orth, Martin F., Verfaillie, Catherine, Grünewald, Thomas G. P., Fendt, Sarah-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437289/
https://www.ncbi.nlm.nih.gov/pubmed/28492237
http://dx.doi.org/10.1038/ncomms15267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437289/
https://www.ncbi.nlm.nih.gov/pubmed/28492237
http://dx.doi.org/10.1038/ncomms15267

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