Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4

The T helper 9 (Th9) cell transcriptional network is formed by an equilibrium of signals induced by cytokines and antigen presentation. Here we show that, within this network, two interferon regulatory factors (IRF), IRF1 and IRF4, display opposing effects on Th9 differentiation. IRF4 dose-dependent...

Descripción completa

Detalles Bibliográficos
Autores principales: Campos Carrascosa, Lucia, Klein, Matthias, Kitagawa, Yohko, Lückel, Christina, Marini, Federico, König, Anika, Guralnik, Anna, Raifer, Hartmann, Hagner-Benes, Stefanie, Rädler, Diana, Böck, Andreas, Kang, Cholho, Lohoff, Michael, Garn, Holger, Schaub, Bianca, Berberich-Siebelt, Friederike, Sakaguchi, Shimon, Bopp, Tobias, Huber, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437292/
https://www.ncbi.nlm.nih.gov/pubmed/28497800
http://dx.doi.org/10.1038/ncomms15366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437292/
https://www.ncbi.nlm.nih.gov/pubmed/28497800
http://dx.doi.org/10.1038/ncomms15366

Ejemplares similares