Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC

Efforts to manipulate locus-specific histone acetylation to assess their causal role in gene expression and cellular and behavioural phenotypes have been impeded by a lack of experimental tools. The Cas9 nuclease has been adapted to target epigenomic modifications, but a detailed description of the...

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Detalles Bibliográficos
Autores principales: Kwon, Deborah Y., Zhao, Ying-Tao, Lamonica, Janine M., Zhou, Zhaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437308/
https://www.ncbi.nlm.nih.gov/pubmed/28497787
http://dx.doi.org/10.1038/ncomms15315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437308/
https://www.ncbi.nlm.nih.gov/pubmed/28497787
http://dx.doi.org/10.1038/ncomms15315

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