A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs

Engineering light-sensitive protein regulators has been a tremendous multidisciplinary challenge. Optogenetic regulators of MAPKs, central nodes of cellular regulation, have not previously been described. Here we present OptoJNKi, a light-regulated JNK inhibitor based on the AsLOV2 light-sensor doma...

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Detalles Bibliográficos
Autores principales: Melero-Fernandez de Mera, Raquel M., Li, Li-Li, Popinigis, Arkadiusz, Cisek, Katryna, Tuittila, Minna, Yadav, Leena, Serva, Andrius, Courtney, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437309/
https://www.ncbi.nlm.nih.gov/pubmed/28497795
http://dx.doi.org/10.1038/ncomms15017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437309/
https://www.ncbi.nlm.nih.gov/pubmed/28497795
http://dx.doi.org/10.1038/ncomms15017

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