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LAV-BPIFB4 isoform modulates eNOS signalling through Ca(2+)/PKC-alpha-dependent mechanism

AIMS: Ageing is associated with impairment of endothelial nitric oxide synthase (eNOS) and progressive reduction in endothelial function. A genetic study on long-living individuals—who are characterized by delays in ageing and in the onset of cardiovascular disease—previously revealed I229V (rs20703...

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Detalles Bibliográficos
Autores principales: Spinelli, Chiara Carmela, Carrizzo, Albino, Ferrario, Anna, Villa, Francesco, Damato, Antonio, Ambrosio, Mariateresa, Madonna, Michele, Frati, Giacomo, Fucile, Sergio, Sciaccaluga, Miriam, Capunzo, Mario, Calì, Gaetano, Milanesi, Luciano, Maciag, Anna, Puca, Annibale Alessandro, Vecchione, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437365/
https://www.ncbi.nlm.nih.gov/pubmed/28419216
http://dx.doi.org/10.1093/cvr/cvx072