Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids

BACKGROUND: Multicellular Tumor Spheroids are frequently used to mimic the regionalization of proliferation and the hypoxic environment within avascular tumors. Here we exploit these features to study the activation of DNA damage repair pathways and their correlation to developing hypoxia. METHODS:...

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Detalles Bibliográficos
Autores principales: Riffle, Stephen, Pandey, Ram Naresh, Albert, Morgan, Hegde, Rashmi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437385/
https://www.ncbi.nlm.nih.gov/pubmed/28521819
http://dx.doi.org/10.1186/s12885-017-3319-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437385/
https://www.ncbi.nlm.nih.gov/pubmed/28521819
http://dx.doi.org/10.1186/s12885-017-3319-0

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