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Survival rates of homozygotic Tp53 knockout rats as a tool for preclinical assessment of cancer prevention and treatment
BACKGROUND: The gene that encodes tumor protein p53, Tp53, is mutated or silenced in most human cancers and is recognized as one of the most important cancer drivers. Homozygotic Tp53 knockout mice, which develop lethal cancers early in their lives, are already used in cancer prevention studies, and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437597/ https://www.ncbi.nlm.nih.gov/pubmed/28536640 http://dx.doi.org/10.1186/s11658-017-0039-z |